Ka hoʻohana ʻana o ʻEhiku Antithrombotic Agents
ʻElua ʻano protein me ka hopena antithrombotic i ka snake venom, hiki i kekahi ke ʻO ka enzyme pili me ka fibrinolytic enzyme i kapa ʻia ʻo fibrinolytic enzyme (plasmine，FLE). hydrolysis o nā kumu coagulation ʻē aʻe a me ka membrane platelet, me ka hopena antithrombotic maopopo.ʻO ka mea ʻē aʻe ma ke kāohi ʻana i ka hoʻomākaukau ʻana o Prothrombin e hoʻolalelale i ke kaʻina coagulation, a ʻaʻohe hana enzyme.
ʻO kēia ʻano enzyme i hana mua ʻia e Atoda et al A kūkākūkā i ke ʻano anticoagulation o ka protein anticoagulant, Ua hōʻoia ʻia ʻo ka hopena o ka coagulation factor IX a i ʻole coagulation factor X ma ka calcium ion Hoʻokumu i ka 1: 1 paʻakikī e hoʻolōʻihi i ka manawa coagulation;Ma hope mai, ʻo Lu et al.mai Agkistrodon acutus ma ka hema o Anhui Ua hoʻokaʻawale ʻia kahi mea anticoagulant ACFI mai ka make ʻawaʻawa.Liu Qing Liang et al.Ua ʻike ʻia aia ka ACFI i ka calcium ion, Ua hōʻoia pū ʻia ʻo kāna hana anticoagulant a me ka hoʻolālā spatial e pili ana i nā ion calcium. Ua ʻike ʻia ka haʻawina hoʻokō mechanical ua like ia me AC FI a no ka ʻāpana ʻelua.ʻO Zhai Ning et al.hoʻokaʻawale i kahi mea anticoagulant neʻe mai ka mea ʻawaʻawa o Agkistrodon acutus, a ua aʻo ʻia kona mau kino kino a me ke kino, a ua ʻike ʻia ʻaʻohe hana fibrinolytic a ʻaʻohe hana phospholipase A 2 a me ka hana koko.Ua hoʻokaʻawale ʻo Qian Xiaojiang a me nā mea ʻē aʻe i ka mea ʻawaʻawa o Agkistrodon acutus mai Hunan Ua hoʻokaʻawale ʻia ka mea hana fibrinolytic a hōʻoia ʻia e ka thrombolytic test in vitro Loaʻa ka hopena thrombolytic maopopo.Ua hoʻokaʻawale ʻia ʻo Lei Danqing e nā ʻano chromatography ʻekolu A ʻoi aku ka maikaʻi o ka hana o ka plasmin.No ka mea i loko o ka ʻāpana plasmin He paʻakikī ke hoʻokaʻawale ʻia ka ʻāpana koko, a ʻaʻole maopopo ka waiwai o kāna noi lapaʻau.Li Zhaoyan et al Ma o ka hooikaika ana e loaa ka fibrinolytic enzyme me ka hookahe ole i ke koko Hāʻawi ʻia ke kākoʻo ʻenehana e.Ua hōʻoia ʻo Zhou Xianli [18] ma o nā hoʻokolohua ʻo Thrombin e like me ka enzyme a me ka plasmin mai Agkistrodon halys venom he hopena thrombolytic maopopo, akā ʻoi aku ka ikaika o ka hopena pololei o ka plasmin ma mua o ka thrombin like enzyme, No laila, ʻo ka thrombin e like me ka enzyme he mea thrombolytic lohi, kahi. hana i ka recanalization o nā kīʻaha koko lohi, Hoʻonui i ka hoʻomanawanui o nā kīʻaha koko ma ka wahi ischemic, a ola i ka vascular rupture i hoʻokumu ʻia e ke koko perfusion He hopena maikaʻi ʻo Cleavage i ka wā mua o ka thrombosis, a hoʻohana pū ʻia nā mea ʻelua, hiki ke hōʻemi. ʻO ka hoʻopaʻa ʻana a hoʻokō i nā hopena anticoagulant a me nā thrombolytic. Ka noi ʻana o ʻEhiku Antithrombotic Agents Aia ʻelua ʻano protein me ka hopena antithrombotic i ka snake venom, hiki i kekahi ke ʻO ka enzyme pili me ka fibrinolytic enzyme kapa ʻia ʻo fibrinolytic enzyme (plasmine，FLE). hoʻohaʻahaʻa i ka fibrin a me ka fibrinogen, ʻAʻohe hana o ka plasminogen i loko o ke kino o ke kanaka, ʻaʻohe hydrolysis o nā mea coagulation ʻē aʻe A me ka membrane platelet, me ka hopena antithrombotic maopopo.ʻO ka mea ʻē aʻe ma ke kāohi ʻana i ka hoʻomākaukau ʻana o Prothrombin e hoʻolalelale i ke kaʻina coagulation, a ʻaʻohe hana enzyme.
ʻO kēia ʻano enzyme i hana mua ʻia e Atoda et al A kūkākūkā i ke ʻano anticoagulation o ka protein anticoagulant, Ua hōʻoia ʻia ʻo ka hopena o ka coagulation factor IX a i ʻole coagulation factor X ma ka calcium ion Hoʻokumu i ka 1: 1 paʻakikī e hoʻolōʻihi i ka manawa coagulation;Ma hope mai, ʻo Lu et al.mai Agkistrodon acutus ma ka hema o Anhui Ua hoʻokaʻawale ʻia kahi mea anticoagulant ACFI mai ka make ʻawaʻawa.Liu Qing Liang et al.ʻike ʻia aia ka ACF i ka calcium ion Ua hōʻoia pū ʻia ʻo kāna hana anticoagulant a me ka hoʻolālā spatial pili i nā ion calcium.Ma hope mai, ua hoʻokaʻawale ʻo Xu Xiaolong a me nā mea ʻē aʻe i ka lāʻau ʻawaʻawa o Agkistrodon acutus mai Agkistrodon acutus me kahi ala hoʻokaʻawale i hoʻomaikaʻi ʻia ʻO kekahi kumu anticoagulant ACFI I Ua ʻike ʻia ka haʻawina hoʻokō mechanical ua like ia me AC FI a no ka ʻāpana ʻelua.ʻO Zhai Ning et al.Ua hoʻokaʻawale ʻia kahi mea anticoagulant hou mai ka mea ʻawaʻawa o Agkistrodon acutus, a ua aʻo ʻia kona mau kino kino a me kemika, a ua ʻike ʻia ʻaʻohe hana fibrinolytic a ʻaʻohe phospholipase A 2 hana a me ke koko.Ua hoʻokaʻawale ʻo Qian Xiaojiang a me nā mea ʻē aʻe i ka mea ʻawaʻawa o Agkistrodon acutus mai Hunan Ua hoʻokaʻawale ʻia ka mea hana fibrinolytic a hōʻoia ʻia e ka thrombolytic test in vitro Loaʻa ka hopena thrombolytic maopopo.Ua hoʻokaʻawale ʻia ʻo Lei Danqing e nā ʻano chromatography ʻekolu A ʻoi aku ka maikaʻi o ka hana o ka plasmin.No ka mea i loko o ka ʻāpana plasmin He paʻakikī ke hoʻokaʻawale ʻia ka ʻāpana koko, a ʻaʻole maopopo ka waiwai o kāna noi lapaʻau.Li Zhaoyan et al Ma o ka hooikaika ana e loaa ka fibrinolytic enzyme me ka hookahe ole i ke koko Hāʻawi ʻia ke kākoʻo ʻenehana e.Ua hōʻoia ʻo Zhou Xianli [18] ma o nā hoʻokolohua ʻo Thrombin e like me ka enzyme a me ka plasmin mai Agkistrodon halys venom he hopena thrombolytic maopopo, akā ʻoi aku ka ikaika o ka hopena pololei o ka plasmin ma mua o ka thrombin like enzyme, No laila, ʻo ka thrombin e like me ka enzyme he mea thrombolytic lohi, kahi. hana i ka recanalization o nā kīʻaha koko lohi, Hoʻonui i ka hoʻomanawanui o nā kīʻaha koko i ka wahi ischemic, a ola i ka vascular rupture ma muli o ke koko perfusion He hopena maikaʻi ʻo Cleavage i ka wā mua o ka thrombosis, a hoʻohana pū ʻia nā mea ʻelua.
Hiki iā ia ke hōʻemi i ka dosage a loaʻa i nā hopena anticoagulant a me thrombolytic.
Ka manawa hoʻouna: ʻOkakopa-19-2022