ʻO ka hopena o ka Tumor Suppressing Component I o Agkistrodon acutus Venom ma ka hana neʻe ʻana o nā ʻāpana endothelial vascular.

No ka nānā ʻana i ka hopena o ka hakina anti-tumor I o Agkistrodon acutus venom (AAVC-1) i ka hana neʻe ʻana o nā pūnaeho endothelial vein umbilical kanaka (HUVECs), a e ʻimi i ke ʻano o ka AAVC - Ⅰ inhibiting angiogenesis.Nā Hana: HUVEC i hoʻoulu ʻia i loko o ka vitro me AAVC - Ⅰ (0, 20, 40, 80 μ G / ml) mālama ʻia nā cell i mālama ʻia no 24 mau hola.Ua hoʻohana ʻia ka hoʻāʻo ʻōpala a me ka hoʻāʻo ʻana o ke keʻena chemotactic e nānā i ka hopena o AAVC - Ⅰ ma ka hana neʻe ʻana o ka endothelial cell;Ua hoʻohana ʻia ʻo RT-PCR a me Western blot e ʻike i nā hoʻololi o ka mRNA a me nā pae protein o P-selectin a me intercellular adhesion factor (ICAM-1) ma mua a ma hope o ka lāʻau lapaʻau.Nā hualoaʻa: Ke hoʻohālikelikeʻia me HU VEC i loko o ka hui maʻamau, ua emi iho ka hiki o ka neʻeʻana o nā pūnaewele i ka AAVC - Ⅰ nā pūʻulu hoʻonaʻauao i nā degere likeʻole, a ua emi loa ka'ōlelo o P-selectin a me ICAM-1 mRNA.Ka hopena: AAVC - Ⅰ hiki ke ho'ēmi i ka'ōlelo o P-selectin a me ICAM-1 mRNA a