Institute of Snake Venom and Snakebite, Ke Koleke Lapaʻau Hema ʻo Anhui

Institute of Snake Venom and Snakebite, Ke Koleke Lapaʻau Hema ʻo Anhui

Ke Keena Imi o Wuhu City, Anhui Province

Ua hoʻomaka ka noiʻi e pili ana i ka ʻawaʻawa nahesa a me ka ʻeha nahesa o Southern Anhui Medical College i ka waena waena o 1970s, a he lālā ʻo ia no ka Hui Pūʻulu Hoʻomaʻamaʻa Nahesa Pane ʻo Anhui i kēlā manawa.ʻO ia kekahi o nā keʻena mua loa e hoʻokō i ka noiʻi kumu a noiʻi ʻia e pili ana i ka ʻawaʻawa nahesa ma Kina.

inoa Pākē

Institute of Snake Venom and Snakebite, Ke Koleke Lapaʻau Hema ʻo Anhui

wahi

Panalaau o Anhui

ʻano ʻano

kula puka

mea

Nahesa Poison a me ka Nahesa Eha

Nā hana noiʻi o ka Institute

Introduction to the Institute

Ua hoʻomaka ka noiʻi e pili ana i ka ʻawaʻawa nahesa a me ka ʻeha nahesa o Southern Anhui Medical College i ka waena waena o 1970s, a he lālā ʻo ia no ka Hui Pūʻulu Hoʻomaʻamaʻa Nahesa Pane ʻo Anhui i kēlā manawa.I ka makahiki 1984, ma lalo o ke alakaʻi ʻana a Professor Wen Shangwu, ka luna o ke keʻena aʻo a me ka noiʻi o nā haumāna maʻi mua, ua hoʻokumu ʻia ka Snake Poison and Snakebite Research Office, ʻo ia kekahi o nā ʻoihana mua loa e hana i ka noiʻi kumu a noiʻi. i ka make nahesa ma Kina.I ka makahiki 2007, ua kapa hou ʻia ke Keʻena ʻimi noiʻi ʻo Snake Poison and Snakebite Research Institute o Southern Anhui Medical College, a ʻo ke alakaʻi o kēia manawa ʻo Professor Zhang Genbao.I loko o nā makahiki he 30 i hala iho nei, ua hoʻokō ʻia nā hana noiʻi kumu a me ka noiʻi ʻana i nā toxins snake venous ma ka hema o Anhui i mea koʻikoʻi i ka pale ʻana a me ka hoʻomalu ʻana i nā ʻeha nahesa a me ka hoʻohana ʻana i nā kumuwaiwai snake ma Kina;ʻO nā moʻo make nui ma ka hema ʻo Anhui ʻo Agkistrodon acutus (Agkistrodon acutus), Agkistrodon acutus, Cobra, Green Bamboo Leaf Snake, Chromium Iron Head a me Bungarus multicinctus, ʻo ia hoʻi ʻo Agkistrodon acutus, ka mea e hoʻopilikia nui i ke olakino a me ke ola o nā kānaka mauna.Ua hōʻike ʻia nā haʻawina e hana nui kēia mau nahesa ʻawaʻawa i ke kahe koko a me nā neurotoxins, hiki ke hōʻeha i ka poʻe maʻi i ka disseminated intravascular coagulation (DIC) a me ka lua o ke koko, ka haʻalulu, ka hemahema o nā okana a me nā hopena koʻikoʻi ʻē aʻe;Ma o kahi noiʻi ʻōnaehana e pili ana i ka toxicology koko o ka mea ʻawaʻawa o Agkistrodon acutus (Agkistrodon acutus) ma ka ʻaoʻao hema o Anhui, ua ʻike ʻia ʻo ka DIC pili me ka nahu nahesa kekahi o nā hōʻailona maoli o ka make mua, a he ʻokoʻa ia mai ka DIC i hōʻike ʻia ma ka moʻomeheu. nā manaʻo.No laila, ʻo ka manaʻo o ka "DIC like" syndrome i nā poʻe maʻi i nahu ʻia e Agkistrodon acutus i manaʻo mua ʻia ma Kina (1988), ua ʻike pū ʻia ʻo thrombin like enzyme (TLE) a me fibrinolytic enzyme (FE) i loko o ka mea make o Agkistrodon acutus. nā kumu nui o kēia "DIC like" (1992).He mea nui kēia no ka wehewehe ʻana i nā ʻano o nā loli koko i nā maʻi me Agkistrodon acutus, a hāʻawi pū i kahi kumu kumu no ka noi ʻana i nā antivenom kūikawā e mālama i kēia hoʻopiʻi.Ma ke aʻo ʻana e pili ana i ke ʻano o ke koko i hoʻokumu ʻia e Agkistrodon acutus venom, ua ʻike pū ʻia ua loaʻa ka hopena o kēia snake i nā mea nui ʻekolu o ka ʻōnaehana hemostatic (coagulation factor, platelets a me nā paia kīʻaha koko), nona ka haemotoxin pololei. pili i ka permeability o nā capillaries.I ka manawa like, ua aʻo ʻia ʻo ke koko koʻikoʻi i hoʻokumu ʻia e ka Agkistrodon acutus venom poisoning a me ka paʻakikī o ka pehu ʻana o nā lālā ʻeha e hoʻohaʻahaʻa e pili ana i ka blockage o ka hoʻohui lymphatic o nā kumu coagulation i loko o ka thoracic duct a me ke kahe o ka lymphatic maikaʻi ʻole.Ua hana nui kēia mau mea noiʻi kumu a me ka noiʻi kumu i ka hana lōʻihi me Qimen Snakebite Research Institute i ka hoʻolālā maikaʻi ʻana i ka hoʻolālā lapaʻau no ka snakebite ʻawaʻawa a me ka hōʻoia ʻana i ka palekana o nā maʻi snakebite, a ua hoʻokō i nā hopena pilikanaka nui.Ua lanakila 'o ka 'imi noi'i i ka 'Epekema a me Technology Achievement Award o Anhui Province, ka Science and Technology Progress Award of Anhui Province (1993), a me ka (A) level Science and Technology Achievement Collective Award of the Ministry of Health (1991);Ma 1989, ua hui pū me Wuhan Institute of Biological Products e hoʻomohala i kahi antibody monoclonal e kūʻē i ka thrombin e like me ka enzyme o Agkistrodon acutus venom, ʻo ia ka lanakila mua ma Kina;I ka makahiki 1996, hana pū ia a hoʻomohala i nā huahana thrombin (YWYZZ 1996 No. 118004, patent CN1141951A) me ka Institute of Biological Products and Drugs of Jinan Military Region.

nā ʻike noiʻi

I nā makahiki i hala iho nei, ua hoʻokaʻawale a hoʻomaʻemaʻe ke keʻena hana i nā ʻano mea bioactive mai nā mea ʻawaʻawa o Agkistrodon acutus, Agkistrodon halys a me Cobra ma ka hema o Anhui, e like me nā enzymes anti hypercoagulable state, protein C activators (PCA).Ua hōʻoia nā haʻawina hoʻokolohua hiki i kēia mau mea ikaika ke hoʻopili i ke kaʻina coagulation, hoʻopili i ka platelet adhesion, aggregation a pale i ka hana o nā cell endothelial vascular, a loaʻa i ka hana kiʻekiʻe a me ka haʻahaʻa haʻahaʻa anticoagulation a me nā hopena thrombolytic, He mea nui kēia no ka pale ʻana a me ka mālama ʻana. nā maʻi thrombotic a me ka hoʻomaikaʻi ʻana i ka hypercoagulability koko;I ka manawa like, ua ʻike pū ʻia ʻo PCA mai ka snake venom ka hopena kikoʻī o ka pepehi ʻana i nā maʻi leukemia K562 a me ka pale ʻana i ka metastasis o nā maʻi kanesa.He ākea loa ka manaʻolana hoʻohana lapaʻau.Ua hoʻokō a hoʻopau ke keʻena noiʻi i nā papahana noiʻi he nui, e like me "Mechanism of DIC i hoʻokumu ʻia e Agkistrodon acutus venom", "Nā noiʻi e pili ana i ke ʻano o ke koko i hana ʻia e Agkistrodon acutus venom i nā holoholona", "Diagnosis of snakebite and differential diagnostic of its ʻohana snake ma ke ʻano hoʻopaʻa inoa enzyme", i kākoʻo ʻia e ka National Natural Science Foundation, ke Kuhina Ola, ke Keʻena ʻOihana Ola a me ke Keʻena Hoʻonaʻauao o Anhui Province;I kēia manawa, ʻo nā papahana i hoʻomohala ʻia: "Nā noiʻi e pili ana i ka Hemorrhagic Anticoagulant Protein o Agkistrodon acutus", "Nā noiʻi e pili ana i ka Molecular Mechanism of the Effect of PCA mai Agkistrodon halys Pallas Venom ma Vascular Endothelial Function", "Nā noiʻi ma ka Molecular Biology of ʻO ka PCA mai Agkistrodon acutus Venom e kū'ē i nā pūnaewele Tumor", a me ka hoʻokaʻawale a me ka hoʻomaʻemaʻeʻana i nā mea analgesic Nerve mai Cobra Venom.

ʻO ke keʻena noiʻi snake venom o South Anhui Medical College he kūlana kumu maikaʻi, nā lako noiʻi piha, ka hui noiʻi kūpono kūpono, a me ka holomua mau i nā ʻano noiʻi a me nā ʻano loea.Manaʻo ʻia e hana i nā mea hou i ka noiʻi ʻepekema, ka hoʻomaʻamaʻa limahana, a me nā mea ʻē aʻe.He lāʻau lapaʻau ʻo Snake venom pharmacy me nā kuleana waiwai naʻauao ma Kina.ʻO nā hopena noiʻi e pili ana i ke kumu a me ka hoʻohana ʻana i ka snake venom a me kāna mau ʻāpana he mea koʻikoʻi nui ia i ka hoʻomohala ʻana i nā kumu waiwai make snake waiwai ma ka hema o Anhui a me ka noi lapaʻau.