Hoʻokaʻawale i nā mea anticoagulant a me fibrinolytic mai Agkistrodon acutus venom

ʻO ka hoʻokaʻawale ʻana o nā mea anticoagulant a me nā fibrinolytic mai Agkistrodon acutus venom a me kā lākou hopena i ka ʻōnaehana coagulation

Pahuhopu: E aʻo i ka hopena o ka thrombin i hoʻomaʻemaʻe ʻia e like me ka enzyme a me ka plasmin mai Agkistrodon acutus venom ma ka ʻōnaehana coagulation koko.

Nā Hana: Ua hoʻokaʻawale ʻia a hoʻomaʻemaʻe ʻia ʻo Thrombin e like me ka enzyme a me ka plasmin mai ka ʻawaʻawa o Agkistrodon acutus e DEAE Sepharose CL-6B a me Sephadex G-75 chromatography, a ua ʻike ʻia ko lākou hopena i nā ʻōkuhi ʻōnaehana coagulation ma o nā hoʻokolohua vivo.Nā hualoaʻa: Ua hoʻokaʻawale ʻia ʻo Thrombin e like me ka enzyme a me ka plasmin mai ka mea ʻawaʻawa o Agkistrodon acutus, a ʻo ko lākou mau paona molekala pili he 39300 a me 26600, kēlā me kēia, ʻo nā thrombin e like me ka enzyme a me ka plasmin mai Agkistrodon acutus venom hiki ke hoʻolōʻihi i ka manawa coagulation koko holoʻokoʻa. ka manawa, ka manawa thrombin a me ka manawa prothrombin, a hoʻemi i ka ʻike o ka fibrinogen, akā ʻoi aku ka ikaika o ka hopena o ka thrombin e like me ka enzyme, ʻoiai ʻo plasmin e hōʻike ana i ka hopena anticoagulant wale nō ma kahi nui nui, a ʻoi aku ka maikaʻi o ka hui ʻana o nā mea ʻelua ma mua o kā lākou hoʻohana hoʻokahi.

Ka hopena:

ʻO ka Thrombin e like me ka enzyme a me ka plasmin mai Agkistrodon acutus venom he hopena i ka ʻōnaehana coagulation koko i nā holoholona, ​​a ʻo ka hui pū ʻana o nā mea ʻelua he hopena anticoagulant maopopo.