ʻO Pharmacokinetics o ka thrombin mai Agkistrodon acutus i nā ʻiole

[Abstract] ʻO Haemocoagulase Acutus (Halase), kahi thermostatic hou i ka hoʻomohala ʻana o ka halase, he thrombobin like enzyme (TLE) kiʻekiʻe i loaʻa mai ka ʻawaʻawa o ka nahesa o Agkistrodon acutus No ke aʻo ʻana i nā pharmacokinetics o Halase, 125Ⅰ-labeled radioisotope ala a me ka radioassay i hui pū ʻia me TCA hoʻohana ʻia ka precip-itate i nā ʻiole.Ua hōʻike ʻia nā hopena i hoʻopili maikaʻi ʻia nā waiwai AUC me nā kau ma lalo o nā ʻano ʻelua i hoʻohana ʻia, a ʻo nā coefficients correlation he 0.999 8 a me 0.999 0 pakahi;ʻO ka nui o ka lāʻau i loko o ke akepaʻa, ka ʻāʻī a me ka puʻuwai i hiki i kona kiʻekiʻe ma hope o 5 mau minuke o ka lawelawe ʻana aʻo ka hapa nui o nā or-gans i hiki i loko o 30 mau minuke, a laila emi mālie;i kēlā me kēia manawa, ʻoi aku ka kiʻekiʻe o ka hoʻopaʻa ʻana i ka lāʻau i loko o ke akepaʻa ma mua o kēlā me nā ʻiʻo ʻē aʻe;Hoʻokuʻu ʻia ʻo Halase a ʻoi loa i ka mimi.He ʻano hou o ka lāʻau hemostatic i hoʻomohala ʻia e kā mākou hui ʻO nā pharmacokinetics o thrombin mai Agkistrodon acutus i nā ʻiole i aʻo ʻia e 125 I-labeled radioisotope method and trichloroacetic acid precipitation i hui pū ʻia me ka radioactive detection.Ua hōʻike nā hualoaʻa i nā koina AUC i anaʻia e nāʻanoʻelua i hoʻopili maikaʻiʻia me ka hōʻailona, ​​aʻo 0.9998 a me 0.9990 nā helu hoʻohui;ʻO ka maʻi o ka lāʻau lapaʻau i loko o ke akepaʻa, ka spleen a me ka puʻuwai ka mea kiʻekiʻe loa o 5 min ma hope o ka hoʻoponopono ʻana, ʻoiai ʻo ka hapa nui o nā ʻiʻo ʻē aʻe ʻo ka 30 min kiʻekiʻe ma hope o ka hoʻoponopono ʻana, a laila emi mālie;I kēlā me kēia manawa, uaʻoi aku ka kiʻekiʻe o ka lāʻau lapaʻau i loko o ke akepaʻa ma mua o nā mea'ē aʻe;Eia kekahi, ua hoʻopau ʻia ka thrombin excretion o Agkistrodon acutus, ma ka mimi